After completing her studies she returned to Pakistan in 1977, planning on a career in the foreign service. Her father Zulfikar Ali Bhutto was Prime Minister at the time. Only weeks after her return military officers led by General Muhammad Zia-ul-Haq overthrew Prime Minister Zulfikar Ali Bhutto in a military coup,a nd arrested her father. Benazir Bhutto spent the next eighteen months in and out of house arrest as she struggled to rally political support to force Zia to drop fallacious murder charges against her father. The military dictator ignored worldwide appeals for clemency and had Zulfikar Bhutto hanged in April of 1979.

Benazir Bhutto's persecution began in earnest after the dismissal of her father's government in 1977 and his execution in 1979 as she intensified her denunciations of Zia and sought to organize a political movement against him. Repeatedly put under house arrest, she was finally imprisoned under solitary confinement in a cell in Sindh province during the summer of 1981. Bhutto described the hellish conditions in her wall less cage in her book "Daughter of the East ":

In her books Daughter of the East, she writes "The summer heat turned my cell into an oven. My skin split and peeled, coming off my hands in sheets. Boils erupted on my face. My hair, which had always been thick, began to come out by the handful. Insects crept into the cell like invading armies. Grasshoppers, mosquitoes, stinging flies, bees and bugs came up through the cracks in the floor and through the open bars from the courtyard. Big black ants, cockroaches, seething clumps of little red ants and spiders. I tried pulling the sheet over my head at night to hide from their bites, pushing it back when it got too hot to breathe."

Released in 1984, she went into exile in Britain until 1986, when martial law was lifted in Pakistan. She returned with a huge crowd numbering in the hundreds of thousands turned out on the streets to greet her, by then the leading symbol of the anti-Zia movement, when she returned to Lahore in April of 1986. Formally elected chair in the following month, Bhutto lost no time in organizing mass protests and civil disobedience campaigns to pressure Zia to relinquish office and call national elections. Bhutto's stirring oratory, familiar name, and striking appearance helped give her a strong mass appeal, but she had to struggle to wrest real power from the PPP's old-guard leadership, members of which were wary of her gender, youth, and political wisdom. Supported by tumultuous crowds, Bhutto again called for fresh elections, resulting in another short prison term that same year. She also had to contend with internal dissension among the anti-Zia forces.

In 1988 Zia was killed in an airplane crash, less than three months after announcing that elections would take place. In the November elections the PPP gained a huge popularity in the National Assembly, and in December 1988 Bhutto, 35 only became prime minister of Pakistan, the first woman to hold this office in any modern Islamic state. During her first term, Her objective was to return Pakistan to civilian rule and oust the men who executed her father, she also started Peoples Program for economic uplift of the masses. Benazir Bhutto lifted a ban on student and trade unions. The PPP. Government hosted the fourth S. A. A. R. C. Summit held in Islamabad, in December 1988.

In August 1990, however, President Ghulam Ishaq Khan dismissed her government using controversial powers which were introduced under military government. After the dismissal of her government, her husband, Mr. Asif Ali Zardari was arrested and imprisoned for over two years on a number of up charges.
In the next elections, which were disputed her party did not secure enough seats to form government and Bhutto became an opposition leader in the parliament. Subsequent attempts to oust the ruling party resulted in Bhutto’s deportation to the city of Karachi in 1992, and she was temporarily banned from entering Islamabad, the capital of Pakistan.

In July 1993, the President of Pakistan dismissed the Government of Prime Minister Mian Nawaz Sharif on corruption charges and called for fresh elections. The Pakistan Peoples Party went to the people in October, 1993 with a new "Agenda for Change". The programme envisaged government at the door-step of the people and priority to the social sectors. Mohtarma Benazir Bhutto was again elected Prime Minister with a broad mandate after achieving strong popular support in all the four provinces of Pakistan .
Bhutto's platform has been leftist, including food for the hungry, health care, jobs, slum clearance and a monthly minimum wage. She has been opposed by Islamic fundamentalists who have been suspicious of the PPP because of its alleged leftist.

Due to Benazir’s Personal world popularity, during her term Pakistan’s relation with other countries improved ,her moderate foreign policy had been credited for improving the wrong image of Pakistan around the world ,however domestically she and her party have been widely blamed for excessive corruption.

Benazir again faced trouble from the opposition. In the autumn of 1994, Nawaz Sharif led a "train march" from Karachi to Peshawar. This was followed by general strike on September 20. Two weeks later Nawaz Sharif called a "wheel jam" strike on October 11.

Once again, using the controversial powers given to the President under Article 58-2 B, elected government of Benazir Bhutto was dismissed from office for the second time in late 1996. Once again a a vendetta was launched against Benazir Bhutto in which politically motivated cases were registered against her and her husband Asif Ali Zardari in order to persecute her and put her under pressure. She denounced all charges as politically motivated, and went into self-imposed exile. Since then she 1999 until 18th October 2007, she remained in exile.

On 18th October 2007 Benazir Bhutto ended her exile and returned to Pakistan and it is estimated that she was received by crowds exceeding 3 million people. This was perhaps the most historic gathering of people in Pakistan. The massive support on the street was evidence that she remains as the most popular leader in Pakistan despite a barrage of disinformation campaign against her.

She has been mentioned as "The world's most popular politician" in the New Guinness Book of Record 1996.
According to The "Times" and the "Australian Magazine" (May 4, 1996) she is one of the 100 most powerful women in the World.
She has received many honoury degrees and awards from several countries.
She also lectures and takes part in several major world events.